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Allergy - Pediatric Rash

Allergy - Pediatric Rash


Allergy - Pediatric Rash
Image Number: 136-048
Media Used: 
Formats Available: Digital
Title: Allergy - Pediatric Rash
Customization: Available
Image Description:  A rash following administration of a drug and IgE –mediated hypersensitivity

© Jackie Heda
Artist/Company Bio:
Jackie Heda is a board certified member of the Association of Medical Illustrators, has been creating art for science and the healthcare industry for 26 years, and has had her own successful business for the past 24 years.
She is actively involved in the AMI, served on the Board of Governors and currently Co-Chair of the Medical Illustration Source Book Editorial Committee. Jackie earned a Bachelor of Science in biology at Emory University and a Bachelor of Science in Art as Applied to Medicine from the University of Toronto. She has received numerous awards for editorial and advertising art.
From her home-based studio in Charlotte, NC, Jackie provides her services to major medical journals, textbook publishers, pharmaceutical companies, and consumer publications. Her illustrations appear in the publication, Harvard Medical School Family Health Guide (Simon & Schuster, 1999). Jackie art directed and illustrated the 24 page full color section in this book, which was featured on NBC's Today show and was listed as one of the top ten medical books for 1999.

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Allergy - Pediatric Rash

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A rash following administration of a drug and IgE –mediated hypersensitivity

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Allergy, Anaphylactic Response. Allergy, Hypersensitivity Anaphylactic Responsecharacterized by excessive activation of mast cells and basophils by IgE, resulting in a systemic inflammatory response that can result in symptoms as benign as a runny nose, to life-threatening anaphylactic shock and death. Type 1 hypersensitivity is an allergic reaction provoked by reexposure to a specific type of antigen referred to as an allergen. Exposure may be by ingestion, inhalation, injection, or direct contact. The difference between a normal immune response and a type I hypersensitive response is that plasma cells secrete IgE. This class of antibodies binds to Fc receptors on the surface of tissue mast cells and blood basophils. Mast cells and basophils coated by IgE are "sensitized." Later exposure to the same allergen, cross-links the bound IgE on sensitized cells resulting in degranulation and the secretion of pharmacologically active mediators such as histamine, leukotriene, and prostaglandin that act on the surrounding tissues. The principal effects of these products are vasodilation and smooth-muscle contraction. The reaction may be either local or systemic. Symptoms vary from mild irritation to sudden death from anaphylactic shock. Treatment usually involves epinephrine, antihistamines, and corticosteroids.

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